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Consequently, PCOS patients frequently exhibit elevated serum iron, ferritin, and transferrin saturation, indicative of a systemic iron-overloaded state ( Iron deficiency, in turn, disrupts glucose homeostasis and promotes IR, thereby forming a vicious cycle with the metabolic disturbances characteristic of PCOS ( 3.2 Ovarian granulosa cell ferroptosis and impaired follicular development Granulosa cells are the primary site of ovarian hormone synthesis and play a crucial role in regulating follicular development, oocyte maturation, and ovulation through hormone secretion

Larger Phase IIb trial: development terminated In 2007, a larger 24-week trial with 536 subjects failed to demonstrate weight loss significant enough to support pharmaceutical viability

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For instance, strategies that enhance oxidative stress can disrupt the balance that parasites rely on for survival