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703 In 2018, the Subcutaneous Drug Delivery and Development Consortium was established, pointing out several major challenges facing optimization of subcutaneous delivery of biotherapeutics, including the need for technological innovations to achieve delivery of high-dose/volume formulations, addressing the insufficient bioavailability of subcutaneous formulations, and eliminating concerns over the higher immunogenicity of the subcutaneous route compared to the intravenous route

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