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Delayed access to effective treatment: Perhaps the most overlooked risk is that using unproven products can delay someone from pursuing treatments that actually have clinical evidence behind them

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35 A prospective cohort study by Ahern et al 36 showed the same pattern of iNKT cell distribution and improvement in psoriasis

Moreover, alternative biologic therapies have been explored for AF treatment, including anakinra (an IL-1 receptor antagonist) used alongside bisphosphonates and corticosteroids for AF with severe osteoarticular symptoms (27), ustekinumab (an interleukin (IL)-12/23 inhibitor) (28), and apremilast (a selective inhibitor of phosphodiesterase 4) (29)