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It modulates the K + /Na + balance by decreased K efflux and increased expression levels of the inward-rectifying potassium channel ( HvAKT1 ), thereby enhancing salt tolerance by maintaining ionic homeostasis [33]

Moreover, given that GLP-1 is a more potent inducer of the beta-cell GLP-1R than glucagon, alpha-cell transcriptional and functional heterogeneity, in terms of GLP-1 production, may importantly affect intra-islet paracrine interactions

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Despite launching in 2019 as the first oral GLP-1 for diabetes, Rybelsus brought in about $2.7 billion in sales for Novo last year, compared to almost $14 billion for Ozempic