In addition to protection of macrovascular complications of T2DM by DPP-4 inhibitors, including linagliptin [29, 43, 84, 117], emerging evidence from clinical studies conducted on small numbers of patients with T2DM reported improvement in microvascular function by linagliptin [30, 49,50,51]
This suggests that the observed reduction in live birth rates was primarily driven by a failure to conceive rather than pregnancy loss
Moreover, glutamine is an important source of amide nitrogen for nucleotide synthesis, and it contributes to the activation of the mTORC1 pathway which promotes mTORC1-dependant metabolic reprogramming, increasing the proliferation and growth of tumors [36-40]
[DOI] [PubMed] [Google Scholar] 2.Kemp M., Go Y.M., Jones D.P