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Important safety considerations include: Increased hypoglycaemia risk when used with insulin or sulfonylureas (dose adjustments of these medications may be needed) Potential worsening of diabetic retinopathy with rapid improvement in blood glucose control, particularly with semaglutide Need for monitoring in patients with pre-existing retinopathy The MHRA continues to monitor the safety profile of these agents

However, some non-peptide GLP-1 agonists are currently being studied in clinical trials, but none are FDA-approved yet

We forget that Vanguards actively managed funds can succeed on performance as well," said Jeff DeMaso, director of research at Adviser Investments and research director for the Independent Adviser for Vanguard Investors newsletter

Available from: Ayoub M, Chela H, Amin N, Hunter R, Anwar J, Tahan V, Daglilar E