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Annu Rev Pharmacol Toxicol 45:5188

Furthermore, the expression of the key glycolytic enzyme PFKFB3 is upregulated and mediates increased PD-L1 expression by activating the nuclear factor B signaling pathway, thereby inhibiting the anti-tumor activity of cytotoxic CD8+ T lymphocytes (82)

Geenen, S

17 It has become clear from studies with the purified enzyme that eNOS may become uncoupled in the absence of the NOS substrate L-arginine or the cofactor BH 4