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doi: 10.1016/j.pnpbp.2019.01.010 23 ChienICLinCHChouYJChouP

Retinal ischemia-hypoxia induced by BRB impairment further triggers neovascularization and nonperfusion, which exacerbates oxidative stress dysregulation and iron metabolism imbalance, forming a vicious positive feedback loop between oxidative stress and BRB damage that accelerates DR pathogenesis and amplifies ferroptosis susceptibility via iron overload and lipid peroxidation