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High-throughput sequencing and dual-luciferase reporter gene analysis show that exercise induces an increase of skeletal muscle exosomes and exosomal miR-484 could enter the brain through blood circulation to inhibit the expression of ACSL4 and thus inhibit ferroptosis of nerve cells

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2 Materials and methods 2.1 Search strategy An online literature search was carried out at PubMed, Web of Science, Embase, Wanfang Data and CNKI, covering 2014 until April 2025