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Common toxicities include infections, gastrointestinal disturbances, amenorrhea, ovarian dysfunction, hematologic cytopenia, hepatic dysfunction, bone marrow suppression, pulmonary toxicity, and others

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MT-II has a cyclic truncated form and acts primarily upon melanocortin receptor 1 (MC1R) and melanocortin receptor 4 (MC4R) , respectively involved in melanogenesis and the regulation of sexual behavior