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2T2DM-1GLP-1GLP-1RGLP-1R GLP-1GLP-1GLP-1+GLP-1GLP-1GLP-1 2023128GLP-13GLP-1NMPA/FDA1GLP-1FDANMPATGA7GLP-1 01GLP-1 GLP-11983 , L GLP-1GLP-17-36GLP-17-37, 30GLP-17-36GLP-17-37 GLP-1GLP-1RGLP-1GLP-1 GLP-1 GLP-1[1] GLP-14dipeptidyl dipeptidase-4DPP-4GLP-1RGLP-1DPP-4 GLP-1 GLP-1 DPP-4 MetforminSimvastatin GLP-1RDPP-4 GLP-1 GLP-1RDPP-4 GLP-1RDPP-4 GLP-1RDPP-4GLP-1RGLP-1 1-2 DPP-4 GLP-1RDPP-4[1] GLP-1R 2 GLP-1RGLP-1R GCGRGLP-2RGIPR GHRHRB1GPCR GLP-1RGGsGiGoGq/11GLP-1GLP-1RGsACcAMPcAMPAPKAcAMP2Epac2 PKA ATP K+ PKA Ca2+VDCC Ca2+ Epac2 Ras 1Rap1 CPLC IP3 DAG Ca2+ GLP-1R [2] 02 GLP-1 80%PEGFc / ExenatideFDA1GLP-1R392Amylin -PLGA1Bydureon20112012FDA GLP-1DOEGLP-1 03 GLP-1 GLP-1AAALACGLP-like / : GLP-1 GLP-1Cetagliptin50mg24DPP-480%GLP-1Cetagliptin D-GLP-1 [3] 04 GLP-1 GLP-1/PK PK Compound A 0.020.050.1 mg/kg CompoundACmax 1:2.8:6.5AUC(0-t)1:2.8:5.7Cmax AUC(0-t)0.02 mg/kg Compound A0.02 mg/kg 82.9% 05 GLP-1 2022930CDEOzempic-1GLP-1/221GLP-1 Ozempic GLP-1 2022829GLP-1105 I GLP-1GLP-1R CDE202320244-5 MDR-001 2023420CDEMDR-0012MDR-001AIMolecule ProGLP-1R202212FDAMDR-001ADMEbest-in-class MDR-001ADMEMDR-001HbA1C MDR-001GLP-1R 06 GLP-1RGLP-1R CRO20INDANDANMPAINDUS FDAIND/ANDANMPAIND/ANDA [1] Baptist Gallwitz

Researchers will evaluate participants through clinical assessments examining classic measures of asthma symptom burden, lung function, and airway inflammation and metabolic and inflammatory markers, insulin, hemoglobin A1c, lipid profiles, and overall frequency of asthma-related events

GLP-1RAs reduces energy and protein intake by suppressing appetite, which may lead to malnutrition and insufficient muscle protein synthesis

Aptamer-functionalized MOFs and AI-driven strategies for early cancer diagnosis and therapeutics