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Since then, several RCTs and meta-analyses have shown beneficial histological improvements after the administration of PIO in individuals with overweight/obesity, prediabetes and T2D who experience NASH

However, this delayed digestion can lead to increased bacterial fermentation of sulphur-containing proteins, producing hydrogen sulphide gas

In addition, the transition from laboratory-scale research to clinical application faces substantial barriers, including extensive preclinical testing to establish safety and efficacy, the complexities of large-scale manufacturing to ensure consistent quality, and the rigorous regulatory approval processes that demand considerable time and resources (Oliva et al., 2021

[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Perzanowski MS, Miller RL, Tang D, Ali D, Garfinkel RS, et al