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It is essential to ensure the treatment is done in a sterile, clinical environment with proper professional oversight

All human specimens were procured and analyzed after obtaining written informed consent with the approval of the Ethics Committees of Graduate School of Medicine, Kyoto University (G562)

Over the past decade, it has been demonstrated that myocardial structure, cardiomyocyte function, and intramyocardial signaling undergo specific alterations in heart failure with preserved ejection fraction (HFpEF)

Although long-standing metabolic disturbances can lead to permanent brain changes, there is reason to hope that, once these perturbations are corrected, rapid improvement will follow