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It should not be used by people with a history of pancreatitis, medullary thyroid cancer, or diabetic retinopathy (a diabetes-related eye disease that damages the blood vessels in the retina)

DPP4 truncates the amino-terminal of the chemokine CXCL10 (also known as IP-10) in chronic hepatitis C virus (HCV) patients, resulting in an antagonist version of the chemokine, which can regulate immune responses through chemokine receptor antagonism