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Furthermore, gene expression analysis of adipocytes differentiated from lipedema-derived stem cells (derived from Stages 13 of lipedema) revealed a significant upregulation of adipogenic markers, such as leptin and PPAR-, compared to healthy non-lipedema adipocytes suggesting an increased adipogenic differentiation potential in lipedema tissue ( Similar to obesity, researchers have observed increased collagen content in lipedema tissue, indicating that fibrosis is also a characteristic of lipedema (Kruppa et al., 2023)

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