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Our findings demonstrate that not all DM2 therapies offer equal neuroprotective benefits, highlighting the need for precision medicine strategies that integrate metabolic, genetic, and environmental factors to optimize treatment selection for individuals at risk of comorbid AD in DM2

Common risks shared with all GLP-1 medications include gastrointestinal side effects - nausea, vomiting, diarrhea, constipation - especially when starting or increasing dose

Ghrelin additionally facilitates lipid uptake into WAT via endothelial GHSR activation [125]

Temperature and viscosity Cold semaglutide solution is slightly more viscous than room-temperature solution