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An extended protocol might look like this: This 32-week escalation requires more total semaglutide (approximately 29.4 mg to reach maintenance) but significantly reduces the chance of side-effect-driven protocol abandonment

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Most people report appetite suppression returning by week 2-3 on tirzepatide, even at the 2.5 mg dose, because the GIP receptor activation adds effects that semaglutide alone could not provide