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Moreover, it was postulated that the aromatic ring of the 3-homotyrosine side chain and the C-terminal phenyl ring interact and Phe550 in IRAP further stabilizes aromatic/hydrophobic packing ( More recently, a crystal structure of IRAP with the macrocyclic peptide inhibitor 23 (HA08) was reported ( 23 (HA08) stabilizes the closed conformation of IRAP

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Eigenschaften und Wirkungen [Bearbeiten | Quelltext bearbeiten] Melanotan II ist ein aus sieben Aminosuren aufgebautes cyclisches Peptid mit der Primrstruktur Ac-Nle- cyclo [Asp-His-D-Phe-Arg-Trp-Lys]-NH 2