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The Effects of GLP-1 Receptor Agonists and SGLT2 Inhibitors on Lean Body Mass: systematic review and meta-analysis of randomised controlled trials

One limitation in existing human studies is that they have been conducted in people with obesity or diabetes, so we do not know if the same brain effects occur in lower BMI populations

They also found that the conjugate has distinct effects on the activity and protein expression of the hypothalamus, a brain region that regulates satiety and is key to the effects of GLP-1 drugs

The depressor axis of the renin-angiotensin system and brain disorders: a translational approach