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The titration regimen described in the NEJM 2023 obesity trial (Jastreboff et al.) progressed as follows: Weeks 14 : 2 mg once weekly Weeks 58 : 4 mg once weekly Weeks 912 : 8 mg once weekly Week 12 onwards : Up to 12 mg once weekly (in higher-dose cohorts) This regimen was used exclusively within a regulated clinical trial setting and does not constitute an approved dosing schedule