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However, the extracellular proteins or ligands that relay environmental signals to Fat1 across the plasma membrane remains elusive, even though some membrane proteins such as KK-LC-1 31 , and secreted proteins such as ISLR and Netrin-1 32,33 have been reported to regulate the Hippo pathway

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In these models, we take into account the reaction geometry of common thiol-disulfide exchange reactions and distinguish hypothetical protein areas that might either interact with the disulfide substrate (a scaffold site) or the reducing agent (an activator site) (Fig