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The hallmark features of the subtype include higher expression of Ki67 (hence higher proliferation rate), lower expression of PR, and in some cases, positive status of HER2 and ER, a more aggressive phenotype with higher chances of early relapse, poor prognosis, lower survival rate, lymph node involvement, and metastasis (99)

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In addition to enhancing existing targeted therapies and chemotherapy, pyroptosis could provide a novel target for AML treatment

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Frontiers in immunology , 13 , 977235 Amelio, I., Cutruzzol, F., Antonov, A., Agostini, M., & Melino, G

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