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Specific cellular processes trigger the activation of distinct metabolic pathways, enabling cell adaption, underscoring the critical role of metabolic fluctuations ( Few studies to date have linked neutrophilic metabolism with cell death, and the comprehensive metabolic features associated with specific types of cell death remain unclear

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This observation, combined with evidence that older adults have blunted MOTS-c responses to exercise, supports the hypothesis that declining mitochondrial peptide signaling contributes to the reduced exercise adaptability seen in aging