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Tirzepatide is not a controlled substance
RC-fed Dpp4 / mice exhibited no detectable plasma DPP4 activity, an approximately 8-fold increase in plasma active GLP-1, reduced fasting glucose, improved glucose tolerance, and no difference in body weight compared with Dpp4 +/+ mice (Figure 2A and Supplemental Figure 1, A and B
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The honest answer: we still don't have enough long-term data
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