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It reversed TBI-induced loss of dendritic density and synaptic connections

Skipping dose levels (e.g., jumping from 0.6 mg to 1.8 mg) should be avoided, as this significantly increases the risk of adverse events

Subsequently, we observed a significant reduction in m in SYNCRIP-deficient cells, indicating mitochondrial impairment (Figure 7A-B)

Wolverine stack protocol: PDA: 500 mcg to 1 mg subcutaneous, once daily TB-500: 2.0 to 2.5 mg subcutaneous, 2 to 3 times weekly (loading phase), then once weekly (maintenance) Duration: 6 to 8 weeks Timing: PDA and TB-500 can be administered at the same time or at different times during the day