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It can be due to emotional distress, hormonal instability, or an underlying pathology like hypertension, diabetes, or peripheral artery disease that can affect the blood flow to the penis or its nerves

Originally identified in intestinal stem cells, LGR5 is now recognized as a marker of CSCs in GBM, colorectal, gastric, and hepatocellular cancers, where its expression is correlated with increased tumor initiation, metastatic potential, and poor prognosis

In AD, melatonin is hypothesized to preserve skin integrity and maintain a functional skin barrier through its antioxidant properties, which include reducing lipid peroxidation and exerting anti-apoptotic effects (103, 104)