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10.1038/s41380-018-0104-7 35

10.1002/med.10051 Med

After several smaller trials, as summarized by others (Quinn, 2018), a phase 3 clinical trial led in 2017 to the approval of L-glutamine for patients with SCD in order to reduce sickle cell-related acute pain crises and hospitalizations (Niihara et al., 2018)

This subcellular localization enables the direct protection of mitochondrial lipids, proteins, and mtDNA from oxidative damage, a critical advantage in diseases like neurodegeneration and metabolic disorders