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Drug therapy: can the mitochondrial adverse effects of antibiotics be exploited to target cancer metabolism

Before diving in, understand: Most evidence is from rodent studies effects in humans may differ No established safe dose range in humans doses are extrapolated from animal work Long-term effects unknown synaptogenesis is powerful

30 Keap1 regulates the transcription factor Nrf2 by promoting its ubiquitination and degradation under normal conditions

Plant Physiol 143:11101118 Ramos J, Naya L, Gay M, Abian J, Becana M (2008) Functional characterization of an unusual phytochelatin synthase, LjPCS3, of Lotus japonicus