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The potential positive results from such a study are strongly suggested by our results

Moreover, the well-tolerated safety profile, with manageable side effects, has made these therapies attractive for long-term use

Chronic sleep deprivation or poor sleep quality impairs these restorative processes, potentially reducing glutathione synthesis capacity and increasing oxidative stress through various mechanisms including increased inflammatory signaling, impaired glucose metabolism, disrupted circadian rhythms affecting antioxidant enzyme expression, and increased psychological stress responses

Extended Data Figure 4 Effects of binding pocket mutations on potency of NAMs