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Thus, the increased sensitivity to RSL3 induced by LDHB silencing in A549 cells is not solely dependent on the CoQ-associated defense mechanism, which is consistent with our previously published study showing that LDHB silencing also affects the GSH-associated defense mechanism in KRAS -mutated lung cancer 24

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It remains to be elucidated whether direct stimulation of the cerebellum can equally suppress tremor or if clinical benefits are better when intervention is earlier or adaptive