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It also prevents the breakdown of collagen

Polyphenols, widely consumed plant-derived compounds, have demonstrated protective effects on the cardiovascular and cerebrovascular systems, with emerging evidence from preclinical stroke models highlighting their neuroprotective potential, even when administered post-stroke (Parrella et al., 2020)

Footnote Nonstandard Abbreviations and Acronyms AM alveolar macrophage EdU 5-ethynyl-2-deoxyuridine GPX4 glutathione peroxidase 4 HIF1 hypoxia-inducible transcription factor 1 IL-1 interleukin-1 LCN2 lipocalin 2 METH methamphetamine METH-PH METH-induced PH NGAL neutrophil gelatinase-associated lipocalin NLRP3 NOD-, LRR-, and pyrin domain-containing protein 3 PASMC pulmonary artery smooth muscle cell PH pulmonary hypertension p-STAT3 phosphorylated STAT3 SLC7A11 solute carrier family 7 member 11 STAT3 signal transducer and activator of transcription 3 WT wild-type -SMA -smooth muscle actin Supplemental Material File (hyp-2024-24548-s03.docx) Expanded Materials and Methods Table S1 Figures S1S10 Download 2.55 MB File (hyp-2024-24548-s04.pdf) Download 21.18 KB References 1