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A second mechanism leading to hepatocellular hyperplasia is a consequence of shifts of existing hepatocyte populations from binucleated hepatocytes to mononucleated cells and shifts from a mononucleated tetraploid hepatocyte to two diploid hepatocytes (cytokinesis without nuclear duplication)

This dual approach supports energy, repair, inflammation, and metabolism more consistently, potentially delaying age-related decline

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The relative high levels of omega-3 polyunsaturated fatty acids exemplified by eicosapentaenoic acid and docosahexaenoic acid detected in roe of male gilt-head bream Sparus aurata and female common cuttlefish Sepia officinalis suggest their potential relevance for nutritional or functional food applications