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doi: 10.1016/j.stem.2016.11.003 13 KurataTTamuraKKanedaHNogamiTUejimaHAsai GoGet al

Because of this and other challenges, employers arent seeing a significant return on their investment or improvements in their employees health. Part of the reason for this low adherence may be attributed to the fact that it can take several months for individuals to work up to the full, effective dose and that some may experience uncomfortable side effects, such as nausea, diarrhea, constipation, vomiting and other gastrointestinal issues contributing to the 10% increase in ER visits that were seen among members after starting a GLP-1

Back Finan, B, Ma, T, Ottaway, M (20 Oct 2013) 'Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans', Science Translational Medicine , 5/209, 2-9a151