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While there is no definitive causal link between the two, both research and clinical experience suggest that extra-esophageal manifestations of GERD, particularly LPR, may contribute to or exacerbate BMS symptoms

Ishizuka M, Watanabe R, Ishii T, Machiyama T, Akita K, Fujita Y, et al

Without Gla on the amino termini of these factors, they no longer bind stably to the blood vessel endothelium and cannot activate clotting to allow formation of a clot during tissue injury