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While it often leads to weight loss, its use specifically for weight loss is considered off-label if not accompanied by a type 2 diabetes diagnosis

However, in Northern Ireland, only those with type 2 diabetes who meet certain criteria can access the drugs on the NHS

Similar patterns occurred with semaglutide/liraglutide combinations, where weight loss continued in mice but plateaued at normal body weight (Figs

GLP-1RAs in nervous system In the nervous system, GLP-1 can decrease oxidative stress and inflammatory responses, potentially through reducing the generation of ROS and decreasing the expression of inflammatory cytokines