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Lnborg J, Vejlstrup N, Kelbk H, et al

The choice should be individualized based on the primary indication (type 2 diabetes versus obesity), efficacy, side effect profile, dosing convenience, cost, and insurance coverage

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Rodent studies involving pharmacological manipulation of GLP-1R in the brain by intracerebroventricular (ICV) administration of agonists and antagonists demonstrate a role for brain GLP-1R signaling in the control of glucose metabolism