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Methadone, in contrast to buprenorphine, fully turns on the opioid receptor, but it also is slow to onset, binds tightly, and stays attached for a long time, Leitz says

SURMOUNT-1 reported up to 22.5% mean body-weight reduction at the highest studied dose over 72 weeks

While the FDA-approved medication isnt directly linked to hair loss, quick weight loss can lead to excessive shedding, which is exactly what Umansky suspects