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While this is usually not a concern for a healthy heart, it is something that people with high blood pressure or tachycardia (a fast heart rate) need to discuss with their doctor

Chronic diarrhea persisting beyond four weeks, even if mild, requires investigation to exclude conditions such as microscopic colitis, bile acid malabsorption, or exocrine pancreatic insufficiency

Injectable semaglutide (Wegovy): In clinical trials , people with obesity taking 2.4 mg of injectable semaglutide once a week lost about 14 pounds in 12 weeks

it can generally be found in drugstores for a low price and is great for sensitive skin, generally not exhibiting adverse effects