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Designing small molecules able to target multiple receptors might sound difficult, but Septerna says the allosteric binding site it has discovered is even better conserved across all incretin receptors than the site targeted by peptides and other small molecule drugs

Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists

doi: 10.1210/endrev/bnaa032, 98 MerchenthalerI.LaneM.ShughrueP

These follow-on patents provide patent protections until 2042.15 This is an additional ten years beyond the main compound patent for semaglutide, which has already benefited from an additional five year extension (Figure 8)