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Downregulating MYCN in IMR-5/75 decreased caspase activation for both treatments, while inducing MYCN expression in SH-SY5Y/MYCN increased caspase activation, although the differences were not statistically significant ( Figure 4D )

extra B12 is excreted if levels are normal Weight Loss: little evidence B12 shots cause weight loss Mood: helps if mood issues come from deficiency but not a standalone depression treatment The key takeaway is that B12's benefits come from correcting a deficiency, not supplying extra boosts to healthy individuals

UK guidance notes that B shots improve energy and prevent nerve damage in deficient patients

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