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These cells play fundamental roles, both in brain development by promoting the maturation of neurons and oligodendrocytes [52] and in the adult brain, by performing functions typical of macrophages such as phagocytosing various types of cellular debris and pathogens, but also regulating and maturing synapses through phagocytosis and the release of various factors, including cytokines, chemokines and extracellular vesicles [53,54]

Consider this example from the SEC, in which an investor makes a $100,000 initial investment that earns 4% a year for 20 years: An investor who pays a 0.25% annual fee versus one paying 1% a year would have roughly $30,000 more after two decades $208,000, versus $179,000.

Curr Opin Clin Nutr Metab Care 27(5):421427

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