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Acknowledgments This work was supported in part by NIH/NIAAA Grant AA016403-01A2 (to J.H.) and by the UNMC Faculty Retention Fund

As seen in Fig 6C, using cells pretransfected with the HP NEG-CTRL under resting conditions as a reference, the expression of ER stress and proinflammatory genes increased in cells transfected with the same control inhibitor, in particular at 48 h