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doi: 10.1038/nn.3109

8.4.2 Mechanistic evidence (preclinical) Song et al

GLP-1 signaling pathway Dysregulation of the GLP-1/GLP-1R signaling cascade, such as diminished ligand secretion, receptor desensitization, or biased signaling, disrupts systemic homeostasis and contributes to pathological states including insulin resistance (IR), -cell dysfunction, endothelial impairment, chronic inflammation, and neurodegeneration

However, the wide distribution of GLP-1 receptor (GLP-1R) in numerous cells prompted the development of the studies investigating possible effects of GLP1 on different organs [33]