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These medications are generally considered for adults with: BMI 30 kg/m or BMI 27 kg/m with conditions such as: Type 2 diabetes High blood pressure Fatty liver Obstructive sleep apnea High cholesterol PCOS Knee osteoarthritis For Asian Indians , treatment decisions may be individualized because obesity-related complications often occur at lower BMI values

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Hormonal fluctuations also cause fat to accumulate in the stomach area and make it harder to maintain muscle mass