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However, niacinamide at physiological doses (like those in prenatal vitamins or moderate supplements) is not known to be harmful

The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition

In such a situation, the ablation of GPx4 has been demonstrated to render tumor cells more susceptible to ferroptosis-eliciting agents, suggesting that GPx4 may emerge as a promising target for the development of novel therapeutic interventions (181, 182)