These drugs stimulate the bone marrow to produce more white blood cells, including neutrophils, and importantly, they allow patients to continue chemotherapy without having to reduce the dose due to side effects, thereby improving therapeutic outcomes (Renner 2012

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the dose of PT-141 may be such that a given patient is not therapeutically responsive to such dose, such as an IN dose of 7.5 mg in a patient responsive only to higher doses, such as 15 or 20 mg of PT-141
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