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Figure 1: Chemical structure of Glutathione [source: Accessed: 10 Oct 2012] The presence of the reactive sulphydryl group (originating from the cysteine residue) gives rise to GSHs nucleophilic nature and so it reacts readily with electrophiles which can present high risk of toxicity to the cell by causing oxidative damage such as lipid peroxidation to cell membranes, and interfering with the activity of essential proteins and DNA synthesis

After recovery from surgery, rats received a vehicle injection and 2 days later were randomly assigned to either of the diet groups (CHOW, fcHS, fcHF, or fcHFHS) and were maintained on their respective diets throughout the remainder of the experiment

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