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Furthermore, no study has compared the pharmacokinetics of NAC in Chinese and Caucasian individuals

Exposure to viruses, bacteria, radiation, environmental toxins, and pollution may deplete glutathione levels, resulting in a buildup of free radicals, which are unstable atoms that can be extremely harmful to the body (Lang et al., 1992)

The oxidative branch of the pentose phosphate pathway (PPP), driven primarily by the enzymes glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD), continues to serve as the dominant metabolic source of NADPH in most cells [42]

In CKD patients, uremic toxins and ROS probably promote inflammation and oxidative stress through the stimulation of polymorphonuclear lymphocytes, leading to the release of inflammatory cytokines