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Andriotis E, Dayan SH (commentary)

These efforts involve chemically masking the secondary amine of MK-801 to render it inactive until the linker is cleaved, by the higher concentration of thiol-containing compounds in the intracellular compartment, resulting in liberation of MK-801 18

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The metabolic effects were linked to alterations in circulating metabolic hormones, including adipokines cell-signaling proteins, hormones, and cytokines that regulate energy metabolism, appetite, inflammation, and immune responses