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This study suggests that liraglutide may effectively reduce body weight and mitigate hyperphagia caused by MC4R deficiency, providing a basis for its potential therapeutic application in patients with MC4R -deficient obesity

These three mechanisms do not operate in isolation

In addition, the distinctions between the GLP-1 analog studies such as LIVE and FIGHT (liraglutide) and SELECT, STEP-HFpEF and STEP-HFpEF DM (semaglutide) are crucial to consider both in terms of their hypotheses, patient populations, endpoints, and their distinct therapeutic contexts

Camp B, Jorde I, Sittel F, Pausder A, Jeron A, Bruder D, Schreiber J, Stegemann-Koniszewski S